TRAINED IMMUNITY-BASED VACCINES: A NEW PARADIGM FOR THE DEVELOPMENT OF BROAD-SPECTRUM ANTI-INFECTIOUS FORMULATIONS

Trained Immunity-Based Vaccines: A New Paradigm for the Development of Broad-Spectrum Anti-infectious Formulations

Challenge with specific microbial stimuli induces long lasting epigenetic changes in innate immune cells that result in their enhanced response to a second challenge by the same or unrelated microbial insult, a process referred to as trained immunity.This opens a new avenue in vaccinology to develop Trained Immunity-based Vaccines (TIbV), defined a

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